Peyronie's disease, a condition of uncertain cause, is characterized by a plaque, or hard lump, that forms on the penis. Cases of Peyronie's disease range from mild to severe. Symptoms may develop slowly or appear overnight. The sexual problems resulting from this disease, can disrupt a couple's physical and emotional relationship and lead to lowered self-esteem for the man. In a small percentage of patients with the milder form of the disease, inflammation may resolve without causing significant pain or permanent bending.
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